Release from or through a Wax Matrix System.I. Basic Release Properties of the Wax Matrix System

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概要

• 論文の詳細を見る

• Release properties from a wax matrix tablet was examined. To obtain basic release properties, the wax matrix tablet was prepared from a physical mixture of drug and wax powder (hydrogenated caster oil) at a fixed mixing ratio. Properties of release from the single flat-faced surface or curved side surface of the wax matrix tablet were examined. The applicability of the square-root time law and of Higuchi equations was confirmed. The release rate constant obtained as g/min^<1/2> changed with the release direction. However, the release rate constant obtained as g/cm^2・min^<1/2> was almost the same. Hence it was suggested that the release property was almost the same and the wax matrix structure was uniform independent of release surface or direction at a fixed mixing ratio. However, these equations could not explain the entire release process. The applicability of a semilogarithmic equation was not as good compared with the square-root time law or Higuchi equation. However, it was revealed that the semilogarithmic equation was available to simulate the entire release process, even though the fit was somewhat poor. Hence it was suggested that the semilogarithmic equation was sufficient to describe the release process. The release rate constant was varied with release direction. However, these release rate constants were expressed by a function of the effective surface area and initial amount, independent of the release direction.

• 公益社団法人日本薬学会の論文
• 2001-11-01

著者

• YONEZAWA Yorinobu

  Faculty of Pharmacy, Meijo University

• Ishida S

  Faculty Of Pharmacy Meijo University

• ISHIDA Sumio

  Faculty of Pharmacy, Meijo University

• Yonezawa Y

  Faculty Of Pharmacy Meijo University

• Yonezawa Yorinobu

  Faculty Of Pharmaceutical Sciences Meijio University

• Sunada H

  Faculty Of Pharmacy Meijo University

• Sunada Hisakazu

  Fac. Of Pharmacy Meijo Univ.

• Sunada Hisakazu

  Faculty Of Pharmacy Meijo University

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