Some Factors Influencing the Dissolution of Solid Dispersions with Nicotinamide and Hydroxypropylmethylcellulose as Combined Carriers

スポンサーリンク

概要

• 論文の詳細を見る

• The dissolution characteristics of solid dispersions with nicotinamide and hydroxypropylmethylcellulose (HPMC) as combined carriers were investigated in water, using nifedipine and nitrendipine as model drugs. The solid dispersions were obtained by the fusion method; after both drug and HPMC dissolved in the fused liquid of nicotinamide at 140℃, the fused mixtures were cooled to solidify them. For nifedipine solid dispersions, the supersaturation behavior was enhanced with a decrease in the viscosity or an increase in the weight fraction of HPMC. Nifedipine was present as an amorphous state even in the solid dispersion with a 1 : 3 : 0.2 weight ratio of drug : nicotinamide : HPMC. Also, the more the weight fraction of nifedipine increased, the more the formation of amorphous drug in solid dispersions was suppressed, thereby lowering the drug supersaturation level. Moreover, the effect of humidity during storage on the dissolution profiles of nifedipine solid dispersions was examined. The humidity caused crystallization of amorphous nifedipine in solid dispersions, and decreased the drug supersaturation level. For nitrendipine solid dispersions, similarly to the nifedipine system, amorphous nitrendipine was obtained in solid dispersions, and this led to the supersaturation phenomenon. However, the inhibitory effect of HPMC on the crystallization of nitrendipine from supersaturated solution was less than that for nifedipine; this is attributable to the lower solubility of nitrendipine crystals. Therefore, the drug dissolution of this ternary dispersion system was influenced by the viscosity and weight fraction of HPMC, the solubility and weight fraction of the drug and the humidity during storage.

• 公益社団法人日本薬学会の論文
• 1998-06-15

著者

• Suzuki Hideshi

  Fuji Laboratory Janssen Pharmaceutical K. K.

• Sunada Hisakazu

  Faculty Of Pharmacy Meijo University

関連論文

• Studies of Rapidly Disintegrating Tablets in the Oral Cavity Using Co-ground Mixtures of Mannitol with Crospovidone
• Preparation of Rapidly Disintegrating Tablets Containing Itraconazole Solid Dispersions
• Rapidly Disintegrating Tablets Prepared by a Surface-Modifying Method : Comparison of Disintegrants
• Preparation and Evaluation of Solid Dispersions of Nitrendipine Prepared with Fine Silica Particles Using the Melt-Mixing Method
• Preparation and Evaluation of Solid Dispersion for Nitrendipine-Carbopol and Nitrendipine-HPMCP Systems Using a Twin Screw Extruder
• Evaluation of Bitterness Suppression of Macrolide Dry Syrups by Jellies
• Preparation and Evaluation of a Compressed Tablet Rapidly Disintegrating in the Oral Cavity
• Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules V. : Release Properties of Ethylcellulose Layered Matrix Granules
• Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules IV. Evaluation of the Controlled Release Properties for in Vivo and in Vitro Release Systems
• Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules III. Effects of the Dissolution Condition on the Release Process
• Analysis of the Release Process of Phenylropanolamine Hydrochloride from Ethylcellulose Matrix Granules II. Effects of the Binder Solution on the Release Process
• Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules
• Preparation of Solid Dispersion for Ethenzamide-Carbopol and Theophylline-Carbopol Systems Using a Twin Screw Extruder
• Improvement of the Dissolution Rate of Nitrendipine Using a New Pulse Combustion Drying Method
• Effect of Several Cellulosic Binders and Method of Their Addition on the Properties and Binder Distribution of Granules Prepared in an Agitating Fluidized Bed
• Effect of Process Variables on the Properties and Binder Distribution of Granules Prepared by a High-Speed Mixer
• Preparation and Evaluation of Combination Tablet Containing Incompatible Active Ingredients
• Release from or through a Wax Matrix System. IV. Generalized Expression of the Release Process for a Reservoir Device Tablet
• Release from or through a Wax Matrix System. III. Basic Properties of Release through the Wax Matrix Layer
• Release from or through a Wax Matrix System. II.^ Basic Properties of Release from or through the Wax Matrix Layer
• Dissolution of Solid Dosage Form. VII. Effect of Shape on the Dissolution of Nondisintegrating Single Component Tablet under Non-sink Condition
• Sustained-Release Progesterone Vaginal Suppositories 1 : Development of Sustained-Release Granule(Biopharmacy)
• Influence of Physicochemical Properties on Drug Release Rate from Hydroxypropylmethylcellulose Matrix Tablets
• Influence of Water-Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers
• Preparation and Evaluation of Ibuprofen Solid Dispersion Systems with Kollidon Particles Using a Pulse Combustion Dryer System
• Some Factors Influencing the Dissolution of Solid Dispersions with Nicotinamide and Hydroxypropylmethylcellulose as Combined Carriers
• Effect of Process Variables on the Properties and Binder Distribution of Granules Prepared in a Fluidized Bed
• Release from or through a Wax Matrix System VI. : Analysis and Prediction of the Entire Release Process of the Wax Matrix Tablet
• Release from or through a Wax Matrix System. V. Applicability of the Square-Root Time Law Equation for Release from a Wax Matrix Tablet
• Release from or through a Wax Matrix System.I. Basic Release Properties of the Wax Matrix System
• Mechanistic Studies on Hydrotropic Solubilization of Nifedipine in Nicotinamide Solution
• Indomethacin Controlled Release Matrix Tablet Prepared by Wet Granulation Procedure
• Comparison of Nicotinamide, Ethylurea and Polyethylene Glycol as Carriers for Nifedipine Solid Dispersion Systems

もっと見る 閉じる

スポンサーリンク