Studies of Rapidly Disintegrating Tablets in the Oral Cavity Using Co-ground Mixtures of Mannitol with Crospovidone

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概要

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• We attempted the development of rapid oral disintegration tabelts by direct compression using co-ground mixture of D-mannitol and crospovidone. The co-ground mixture was prepared with a vibration rod mill. The tablets were formed by compression using a single punch-talbeting machine after addition of the co-ground mixture to non-ground D-mannitol, crospovidone and magnesium stearate. Regarding the properties of tablets, hardness and the time of disintegration were measured. The particle diamter and specific surface area of the co-ground mixture were measured. The talbets manufactured from a physical mixture of 30%(w/w)co-ground mixture of D-mannitol and crospovidone(mixed ratio 9:1)with 65.5%(w/w)of non-ground mannitol, 4%(w/w)of crospovidone, and 0.5%(w/w)of magnesium stearate had good properties for rapidly disintegrating tablets in the oral cavity. They showed the hardness of 4.9kg and disintegration time of 33s. We found that adding co-ground mixture of D-mannitol and crospovidone is useful in enhancing hardenss of the tablets that could not be achieved by addition of their individually ground mixture. The improvement in the hardness of the tablets was also observed when other saccarides and disintegrants were used. This method was proved to be applicable in the manufacture of tables of ascorbic acid, a water-soluble drug and nifedipine, a slightly water soluble drug ; and the dissolution rate of nifedipine from the tablets in water was remarkably improved. The particle sizes of D-mannitol in the co-ground mixture were smaller than that of the individually ground mixture, resulting in a larger specific surface area of the co-ground mixture than that of the individually ground mixture. Therefore, it was presumed that crospovidone acted as a grinding assistant for D-mannitol in the co-grinding process, enhancing the hardness of teablets by increasing the contact area among powder particles.

• 2002-02-01

著者

• Suzuki Hideshi

  Fuji Laboratory Janssen Pharmaceutical K. K.

• SHU Toshifusa

  Fuji Laboratory, JANSSEN PHARMACEUTICAL K.K.

• HIRONAKA Kenji

  Fuji Laboratory, JANSSEN PHARMACEUTICAL K.K.

• ITO Kunio

  Fuji Laboratory, JANSSEN PHARMACEUTICAL K.K.

• Shu Toshifusa

  Fuji Laboratory Janssen Pharmaceutical K.k.

• Hironaka Kenji

  Fuji Laboratory Janssen Pharmaceutical K.k.

• Ito Kunio

  Fuji Laboratory Janssen Pharmaceutical K.k.

関連論文

• Studies of Rapidly Disintegrating Tablets in the Oral Cavity Using Co-ground Mixtures of Mannitol with Crospovidone
• Influence of Water-Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers
• Some Factors Influencing the Dissolution of Solid Dispersions with Nicotinamide and Hydroxypropylmethylcellulose as Combined Carriers
• Mechanistic Studies on Hydrotropic Solubilization of Nifedipine in Nicotinamide Solution
• Comparison of Nicotinamide, Ethylurea and Polyethylene Glycol as Carriers for Nifedipine Solid Dispersion Systems

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