Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules

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概要

• 論文の詳細を見る

• The release properties of phenyipropanolamine hydrochloride (PPA) from ethylcellulose (EC, ethylcellulose 10 cps (EC#10) and/or 100 cps (EC#100)) matrix granules prepared by the extrusion granulation method were examined. The release process could be divided into two parts, and was well analyzed by applying square-root time law and cube root law equations, respectively. The validity of the treatments was confirmed by the fitness of the simulation curve with the measured curve. At the initial stage, PPA was released from the gel layer of swollen EC in the matrix granules. At the second stage, the drug existing below the gel layer dissolved, and was released through the gel layer. Also, the time and release ratio at the connection point of the simulation curves was examined to determine the validity of the analysis. Comparing the release properties of PPA from the two types of EC matrix granules, EC#I00 showed more effective sustained release than EC#10. On the other hand, changes in the release property of the EC#10 matrix granule were relatively more clear than that of the EC#100 matrix granule. Thus, it was supposed that EC#10 is more available for controlled and sustained release formulations than EC#100.

• 公益社団法人日本薬学会の論文
• 2002-11-01

著者

• Fujii R

  Pharmaceutical Discovery Research Division Takeda Chemical Industries Ltd.

• SUNADA Hisakazu

  Faculty of Pharmacy, Meijo University

• FUKUI Atsuko

  Ryukakusan Co., Ltd.

• FUJII Ryuta

  Ryukakusan Co., Ltd.

• YONEZAWA Yorinobu

  Faculty of Pharmacy, Meijo University

• Fujii R

  Ryukakusan Co. Ltd.

• Fukui Atsuko

  Ryukakusan Co. Ltd.

• Yonezawa Y

  Faculty Of Pharmacy Meijo University

• Yonezawa Yorinobu

  Faculty Of Pharmaceutical Sciences Meijio University

• Sunada H

  Faculty Of Pharmacy Meijo University

• Sunada Hisakazu

  Fac. Of Pharmacy Meijo Univ.

• Sunada Hisakazu

  Faculty Of Pharmacy Meijo University

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