Sustained-Release Progesterone Vaginal Suppositories 1 : Development of Sustained-Release Granule(Biopharmacy)
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概要
- 論文の詳細を見る
Progesterone (P) is an important hormone for the establishment of pregnancy, and its administration is useful for luteal insufficiency. Considering the problems of commercially available oral and injection drugs, hospital-formulated vaginal suppositories are clinically used. However, since the half-life of P suppositories is short, it is difficult to maintain its constant blood concentration. To sustain drug efficacy and prevent side-effects, we are attempting to develop sustained-release suppositories by examining the degree of sustained-release of active ingredients. In this study, we examined the combinations of granulation methods and release systems for the preparation of sustained-release granules of P, and produced 13 types of sustained-release granules. We also examined the diameter, content, and dissolution of each type of granules, and confirmed that the sustained-release of all types of granules was satisfactory. Among the sustained-release granules, we selected granules with a content and a degree of sustained-release suitable for sustained-release suppositories.
- 公益社団法人日本薬学会の論文
- 2009-02-01
著者
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Ohno Yukiko
Faculty Of Pharmacy Meijo University
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OKAMOTO Hirokazu
Faculty of Pharmaceutical Sciences, Kyoto University
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Nakayama Ayako
Department Of Environmental Science Kobe College
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Nakayama Ayako
Department Of Pharmacy Hoshigaoka Maternity Hospital:graduate School Of Environmental And Human Scie
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Sunada Hisakazu
Faculty Of Pharmacy Meijo University
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FURUHASHI Kaoru
Faculty of Pharmacy, Meijo University
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ITO Mikio
Graduate School of Environmental and Human Sciences & Faculty of Pharmacy, Meijo University
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Ito Mikio
Graduate School Of Environmental And Human Sciences & Faculty Of Pharmacy Meijo University
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Furuhashi Kaoru
Faculty Of Pharmacy Meijo University
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