Lactose as a Low Molecular Weight Carrier of Solid Dispersions for Carbamazepine and Ethenzamide
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概要
- 論文の詳細を見る
Solid dispersions of carbamazepine or ethenzamide were prepared by melting and rapid cooling with liquid nitrogen using lactose as a carrier. The physical characteristics of these solid dispersions were investigated by powder X-ray diffraction, differential scanning calorimetry, and dissolution rate analysis. The degree of crystallinity of the drugs in solid dispersions decreased with decreases in the molar ratio of the drugs to lactose. Fourier-transform infrared (FT-IR) analysis demonstrated the presence of intermolecular hydrogen bonds between the primary amide group of carbamazepine and lactose. Dissolution studies indicated that the dissolution rate was markedly increased in solid dispersions compared with physical mixtures and pure drugs. These results indicated that lactose is useful as a carrier for the production of solid dispersions of drugs having a primary amide group in their structures.
- 公益社団法人日本薬学会の論文
- 1999-03-15
著者
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Danjo Kazumi
Faculty Of Pharmacy Meijo University
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OKAMOTO Hirokazu
Faculty of Pharmaceutical Sciences, Kyoto University
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Okamoto Hirokazu
Faculty Of Pharmacy Meijo University
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HIRASAWA Noriyuki
Faculty of Pharmacy, Meijo University
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Hirasawa Noriyuki
Faculty Of Pharmacy Meijo University
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