Studies on the Number of Contacts between Ibuprofen and Ethenzamide Using Thermal Analysis
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概要
- 論文の詳細を見る
We studied a method of estimating the number of contacts in a solid dosage form using thermal analysis. Ibuprofen (IB) and Ethenzamide (ET) were used as model actives. IB and ET were granulated and sieved with each other. We prepared mixtures of IB and ET using different diameter granules. The number of contacts between the samples was calculated by the expression method of Ouchiyama and Tanaka. By thermal analysis, we measured the quantity of endotherm up to 60-63℃ from 56℃. The quantity of endotherm up to 61℃ from 56℃ was in good proportion to the number of contacts calculated by the expression.
- 公益社団法人日本薬学会の論文
- 2000-01-01
著者
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Danjo Kazumi
Faculty Of Pharmacy Meijo University
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Mizutani Taku
Research Center, Taisho Pharmaceutical Co., LTD.
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Aoki Shinji
Research Laboratory Taisho Pharmaceutical Co. Ltd.
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Mizutani T
Research Laboratory Taisho Pharmaceutical Co. Ltd.
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Mizutani Taku
Research Center Taisho Pharmaceutical Co. Ltd.
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