Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules V. : Release Properties of Ethylcellulose Layered Matrix Granules
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概要
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In the pharmaceutical preparation of a controlled release drug, it is very important and necessary to understand the release properties. In previous papers, a combination of the square-root time law and cube-root law equations was confirmed to be a useful equation for qualitative treatment. It was also confirmed that the combination equation could analyze the release properties of layered granules as well as matrix granules. The drug release property from layered granules is different from that of matrix granules. A time lag occurs before release, and the entire release property of layered granules was analyzed using the combination of the square-root time law and cube-root law equations. It is considered that the analysis method is very useful and efficient for both matrix and layered granules. Comparing the granulation methods, it is easier to control the manufacturing process by tumbling granulation (method B) than by tumbling-fluidized bed granulation (method C). Ethylcellulose (EC) layered granulation by a fluidized bed granulator might be convenient for the preparation of controlled release dosage forms as compared with a tumbling granulator, because the layered granules prepared by the fluidized bed granulator can granulate and dry at the same time. The time required for drying by the fluidized bed granulator is shorter than that by the tumbling granulator, so the fluidized bed granulator is convenient for preparation of granules in handling and shorter processing time than the tumbling granulator. It was also suggested that the EC layered granules prepared by the fluidized bed granulator were suitable for a controlled release system as well as the EC matrix granules.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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Fujii R
Pharmaceutical Discovery Research Division Takeda Chemical Industries Ltd.
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SUNADA Hisakazu
Faculty of Pharmacy, Meijo University
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FUKUI Atsuko
Ryukakusan Co., Ltd.
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FUJII Ryuta
Ryukakusan Co., Ltd.
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YONEZAWA Yorinobu
Faculty of Pharmacy, Meijo University
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Fujii R
Ryukakusan Co. Ltd.
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Fukui Atsuko
Ryukakusan Co. Ltd.
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Yonezawa Y
Faculty Of Pharmacy Meijo University
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Yonezawa Yorinobu
Faculty Of Pharmaceutical Sciences Meijio University
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Sunada H
Faculty Of Pharmacy Meijo University
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Sunada Hisakazu
Fac. Of Pharmacy Meijo Univ.
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Sunada Hisakazu
Faculty Of Pharmacy Meijo University
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