Preparation and Evaluation of Solid Dispersion for Nitrendipine-Carbopol and Nitrendipine-HPMCP Systems Using a Twin Screw Extruder

スポンサーリンク

概要

• 論文の詳細を見る

• In the present study, we prepared solid dispersions of the poorly water-soluble drug nitrendipine (NIT) using the twin screw extruder method with high-molecular-weight substances, hydroxypropylmethylcellulosephthalate (HPMCP) and Carbopol (CAR), as carriers. Powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) evaluation showed that solid dispersions can be formed when NIT-HPMCP and NIT-CAR mixtures are treated with the twin screw extruder method. Fourier Transformation IR Spectroscopy (FT-IR) obtained with NIT-HPMCP and NIT-CAR solid dispersions indicated the presence of hydrogen bonding between the drug and the carriers. NIT-CAR solid dispersions were found to give somewhat higher dissolution than crystalline NIT and physical mixtures, while the dissolution of NIT-HPMCP solid dispersions was markedly decreased compared with the crystalline NIT and physical mixtures. These findings indicated that CAR has a greater ability to improve the dissolution of NIT than HPMCP when a twin screw extruder was employed to prepare the solid dispersions. The twin screw extruder method can be used as a simple and effective method for the preparation of solid dispersions to improve the dissolution properties of poorly water-soluble drugs when choosing proper polymers as carriers.

• 社団法人日本薬学会の論文
• 2005-10-01

著者

• Wang Liang

  Dep. Of Pharmaceutics Shenyang Pharmaceutical Univ.

• SUNADA Hisakazu

  Faculty of Pharmacy, Meijo University

• WANG Liang

  Department of Pharmaceutics, Shenyang Pharmaceutical University

• CUI Fu

  Department of Pharmaceutics, Shenyang Pharmaceutical University

• HAYASE Tomokazu

  Faculty of Pharmacy, Meijo University

• Cui Fu

  Department Of Pharmaceutics Shenyang Pharmaceutical University

• Hayase Tomokazu

  Faculty Of Pharmacy Meijo University

• Wang Liang

  Department Of Pharmaceutics Shenyang Pharmaceutical University

• Sunada H

  Faculty Of Pharmacy Meijo University

• Sunada Hisakazu

  Fac. Of Pharmacy Meijo Univ.

• Sunada Hisakazu

  Faculty Of Pharmacy Meijo University

• Wang Liang

  Department Of Pharmaceutical Sciences School Of Pharmacy And Pharmaceutical Sciences University At B

• WANG Liang

  Department of Hematologic Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center

関連論文

• Preparation of Rapidly Disintegrating Tablets Containing Itraconazole Solid Dispersions
• Rapidly Disintegrating Tablets Prepared by a Surface-Modifying Method : Comparison of Disintegrants
• Effect of Several Cellulosic Binders on Particle Size Distribution of Granules Prepared by a High-Speed Mixer
• Preparation and Evaluation of Solid Dispersions of Nitrendipine Prepared with Fine Silica Particles Using the Melt-Mixing Method
• Preparation and Evaluation of Solid Dispersion for Nitrendipine-Carbopol and Nitrendipine-HPMCP Systems Using a Twin Screw Extruder
• Evaluation of Bitterness Suppression of Macrolide Dry Syrups by Jellies
• Preparation and Evaluation of a Compressed Tablet Rapidly Disintegrating in the Oral Cavity
• Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules V. : Release Properties of Ethylcellulose Layered Matrix Granules
• Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules IV. Evaluation of the Controlled Release Properties for in Vivo and in Vitro Release Systems
• Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules III. Effects of the Dissolution Condition on the Release Process
• Analysis of the Release Process of Phenylropanolamine Hydrochloride from Ethylcellulose Matrix Granules II. Effects of the Binder Solution on the Release Process
• Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules
• Preparation of Solid Dispersion for Ethenzamide-Carbopol and Theophylline-Carbopol Systems Using a Twin Screw Extruder
• Improvement of the Dissolution Rate of Nitrendipine Using a New Pulse Combustion Drying Method
• Effect of Several Cellulosic Binders and Method of Their Addition on the Properties and Binder Distribution of Granules Prepared in an Agitating Fluidized Bed
• Effect of Process Variables on the Properties and Binder Distribution of Granules Prepared by a High-Speed Mixer
• Preparation and Evaluation of Combination Tablet Containing Incompatible Active Ingredients
• Release from or through a Wax Matrix System. IV. Generalized Expression of the Release Process for a Reservoir Device Tablet
• Release from or through a Wax Matrix System. III. Basic Properties of Release through the Wax Matrix Layer
• Release from or through a Wax Matrix System. II.^ Basic Properties of Release from or through the Wax Matrix Layer
• Dissolution of Solid Dosage Form. VII. Effect of Shape on the Dissolution of Nondisintegrating Single Component Tablet under Non-sink Condition
• Sustained-Release Progesterone Vaginal Suppositories 1 : Development of Sustained-Release Granule(Biopharmacy)
• Influence of Physicochemical Properties on Drug Release Rate from Hydroxypropylmethylcellulose Matrix Tablets
• Influence of Water-Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers
• Preparation and Evaluation of Ibuprofen Solid Dispersion Systems with Kollidon Particles Using a Pulse Combustion Dryer System
• Some Factors Influencing the Dissolution of Solid Dispersions with Nicotinamide and Hydroxypropylmethylcellulose as Combined Carriers
• Effect of Process Variables on the Properties and Binder Distribution of Granules Prepared in a Fluidized Bed
• Release from or through a Wax Matrix System VI. : Analysis and Prediction of the Entire Release Process of the Wax Matrix Tablet
• Release from or through a Wax Matrix System. V. Applicability of the Square-Root Time Law Equation for Release from a Wax Matrix Tablet
• Release from or through a Wax Matrix System.I. Basic Release Properties of the Wax Matrix System
• Mechanistic Studies on Hydrotropic Solubilization of Nifedipine in Nicotinamide Solution
• Indomethacin Controlled Release Matrix Tablet Prepared by Wet Granulation Procedure
• Comparison of Nicotinamide, Ethylurea and Polyethylene Glycol as Carriers for Nifedipine Solid Dispersion Systems
• Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine
• mTOR and PTEN expression in non-small cell lung cancer : analysis by real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry
• Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type : 13-year follow-up in 135 patients

もっと見る 閉じる

スポンサーリンク