ENHANCEMENT OF LYMPHATIC TRANSPORT OF 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL BY POLYACRYLIC ACID AQUEOUS GEL AND EMULSION TYPE SUPPOSITORIES IN RATS
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概要
- 論文の詳細を見る
1-(2-Tetrahydrofuryl)-5-fluorouracil (FT-207) concentrations in lymph and plasma were measured after rectal administration of three types of suppositories containing FT-207. The suppositories used in this study were prepared from polyacrylic acid aqueous gel bases, emulsion type bases and a commercial fat base, witepsol w-35. Both aqueous gel and emulsion type suppositories were superior to the suppositories fromwitepsol with regard to FT-207 concentration in lymph and plasma. The addition of aqueous gel to the polyacrylic acid aqueous gel was found to be effective for the lymph transport from the aqueous gels. Polyacrylic acid aqueous gel containing 1% glycyrrhizin was better than other suppositories. Solidification of the emulsion type bases are also investigated, and it is suggested that these may be better substitutes of the oily suppository.
- 公益社団法人日本薬学会の論文
著者
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YASUDA Masahide
Osaka University of Pharmaceutical Sciences
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Morimoto Kazuhiro
Osaka College Of Pharmacy
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MORISAKA KATSUAKI
Osaka College of Pharmacy
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OTSUKA Akinobu
Faculty of Pharmacy, Meijo University
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YONEZAWA Yorinobu
Faculty of Pharmacy, Meijo University
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Otsuka Akinobu
Faculty Of Pharmaceutical Sciences Meijio University
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Yasuda Masahide
Osaka College Of Pharmacy
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TAKEEDA TOSHIYUKI
Osaka College of Pharmacy
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NAKAMOTO YASUO
Osaka College of Pharmacy
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KAMIYA ETSUKO
Osaka College of Pharmacy
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Yonezawa Yorinobu
Faculty Of Pharmaceutical Sciences Meijio University
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