The Natural Intron Sequence of Human Tyrosine Pre-transfer RNA Is Not a Temporal Stabilizer for Cloverleaf Structure

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概要

• 論文の詳細を見る

• We have developed the hyperprocessing technique to evaluate the stability of the cloverleaf shape of pre-transfer RNA (pre-tRNA). Application of this strategy to hyperprocessible human tyrosine pre-tRNA indicated that the natural intron sequence did not contribute to stabilization of the cloverleaf shape of this pre-tRNA, while the artificial intron with elongated anticodon-stem completely inhibited hyperprocessing of it. Our data suggested that the contemporary intron sequence may be a vestige of the ancient pre-biotic world, but not has been retained as a temporal stabilizer of the pre-tRNA before the base modifications.

• 社団法人 日本農芸化学会の論文
• 2004-08-23

著者

• Ando T

  Department Of Applied Biological Science Faculty Of Agriculture Tokyo University Of Agriculture And

• Ando Tomoaki

  Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O

• Tanaka T

  Bio-organic Chemistry Laboratory Institute For Fundamental Research Suntory Research Center

• Tanaka Takaaki

  Graduate School Of Science And Technology Niigata University

• Ando T

  Graduate School Of Bio-applications And Systems Engineering (base) Tokyo University Of Agriculture A

• Kikuchi Y

  Div. Of Life Sci. And Biotechnology Dep. Of Ecological Engineering Toyohashi Univ. Of Technol.

• Kikuchi Yo

  Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O

• Kikuchi Yo

  Division Of Bioscience And Biotechnology Department Of Ecological Engeneering Toyohashi University O

• TANAKA Terumichi

  Division of Life Science and Biotechnology, Department of Ecological Engineering, Toyohashi Universi

• Tanaka T

  Division Of Life Science And Biotechnology Department Of Ecological Engineering Toyohashi University

• Kikuchi Y

  Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O

• Tanaka Terumichi

  Division Of Bioscience And Biotechnology Department Of Ecological Engeneering Toyohashi University O

• Ando Tetsu

  Graduate School Of Bio-applications And Systems Engineering Tokyo University Of Agriculture And Tech

• Tanaka Takaaki

  Department Of Materials Science And Technology Faculty Of Engineering Niigata University

• Tanaka Terumichi

  Graduate School of Science and Technology, Niigata University

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