Formation of Lysophosphatidic Acid, a Wound-Healing Lipid, during Digestion of Cabbage Leaves
スポンサーリンク
概要
- 論文の詳細を見る
Lysophosphatidic acid (LPA) is a lipid mediator that plays a role in the process of wound healing in animal tissues, including the digestive tract. We determined LPA in several foodstuffs, and found that cabbage leaves were the richest source of LPA. We also found that, at 22 and 195 nmol/g (wet weight), LPA and phosphatidic acid (PA) were respectively formed during mastication of raw cabbage leaves and that the resulting PA was converted to LPA by pancreatic phospholipase A2. The lipid extract obtained from ground cabbage leaves promoted the proliferation of Swiss 3T3 fibroblasts and the motility of HGC-27 cells, stomach-derived epithelial-like cells, at physiologically relevant concentrations. These activities of cabbage lipids were inhibited by Ki16425, an LPA-receptor antagonist. LPA formed during the digestion of cabbage leaves may be one of the components in the beneficial effect of ingested cabbage on a damaged digestive tract.
- 社団法人 日本農芸化学会の論文
- 2009-06-23
著者
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KOIKE Tohru
Department of Functional Molecular Science, Division of Medicinal Chemistry, Graduate School of Biom
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Koike Tohru
Dep. Of Functional Molecular Sci. Graduate School Of Biomedical Sciences Hiroshima Univ.
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Hirano Kaoru
Dep. Of Applied Biological Sci. Fukuyama Univ.
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Tanaka T
Biofrontier Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Tanaka T
Hiroshima Univ. Higashi Hiroshima Jpn
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HIRANO Kaoru
Department of Applied Biological Science, Fukuyama University
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TANAKA Tamotsu
Department of Applied Biological Science, Fukuyama University
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SATOUCHI Kiyoshi
Department of Applied Biological Science, Fukuyama University
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Tanaka T
Bio-organic Chemistry Laboratory Institute For Fundamental Research Suntory Research Center
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Tanaka Takaaki
Graduate School Of Science And Technology Niigata University
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Koike Tohru
Department Of Applied Chemistry National Defense Academy
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Satouchi K
Dep. Of Applied Biological Sci. Fukuyama Univ.
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Tanaka Tamotsu
Department Of Applied Biological Science Fukuyama University
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HORIUCHI Gou
Department of Applied Biological Science, Fukuyama University
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MATSUOKA Megumi
Department of Applied Biological Science, Fukuyama University
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TOKUMURA Akira
Institute of Health Biosciences, University of Tokushima Graduate School
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Tanaka T
Division Of Life Science And Biotechnology Department Of Ecological Engineering Toyohashi University
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Hirano Kaoru
Department Of Applied Biological Science Fukuyama University
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Tokumura Akira
Institute Of Health Biosciences University Of Tokushima Graduate School
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Matsuoka Megumi
Department Of Applied Biological Science Fukuyama University
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Satouchi Kiyoshi
Department Of Applied Biological Science Fukuyama University
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Horiuchi Gou
Department Of Applied Biological Science Fukuyama University
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Tanaka Takaaki
Department Of Materials Science And Technology Faculty Of Engineering Niigata University
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Tanaka Terumichi
Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O
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Tanaka Terumichi
Graduate School of Science and Technology, Niigata University
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