EXTRINSIC AUTONOMIC NERVOUS REGULATION OF THE BILIARY SYSTEM IN DOGS

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The extrinsic autonomic nervous regulation of the biliary system was investigated in anesthetized dogs.<BR>Bilateral cervical vagotomy caused the decreases of perfusion pressure through the sphincter of Oddi, intramural duodenal pressure and gallbladder pressure. These responses were affected slightly by bilateral splanchnicotomy and then were recovered by bilateral adrenalectomy. Bilateral splanchnicotomy had no effect on the perfusion pressure through the sphincter of Oddi and the intramural duodenal pressure. The perfusion pressure through the sphincter of Oddi and the intramural duodenal pressure were increased by right vagal stimulation and this increase were inhibited by atropine. The perfusion pressure through the sphincter of Oddi and the intramural duodenal pressure were decreased by left great splanchnic nerve stimulation. These responses were inhibited by propranolol, phentolamine or bilateral adrenalectomy. The splanchnic nerve stimulation caused decrease or increase in the gallbladder pressure. This increase was inhibited by phentolamine, and the decrease was inhibited by propranolol.<BR>In conclusion, the vagus nerve is the extrinsic factor which acts predominantly on the biliary system. The decrease of pressure in biliary system by bilateral vagotomy is partially mediated through the adrenal gland. Splanchnic nerve acts to inhibit the movement to Oddi muscle through relaxation-mediating β-receptors.
日本平滑筋学会の論文