諸種薬物の視床下部に関する薬理学的検索-3-特にウサギ視床下部電気刺激時の情動行動に対する作用

概要

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1) A relationship was determined among flight behavior, stimulus parameters and sites. 2) Utilizing tracing apparatus of behavior using the photometric technique, characteristics of flight behavior were recorded. Difficulties in the twisting wire were removed by using a special type rotating connector through which the electrical signals induced in the stimulator were transmitted into the brain. 3) Nitrazepam in the amount of 1_??_10mg/kg (i. p.) caused a depression in the flight behavior, and at the same time the appearance of general behavior including muscle relaxation, sedation and ataxia. When the same drug, as much as 1_??_50mg/kg (p. o.), was administrated, the flight depression, which was not always dose dependent, was resulted. 4) The administration of diazepam as much as 1_??_10mg/kg (p. o.) resulted in a moderate depression of flight behavior, and the less depression in the general behavior as compared with nitrazepam. 5) Chlordiazepoxide showed a marked increase of threshold at 50mg/kg (p. o.), but a lower dose of 10_??_20mg/kg (p. o.) did not result in any significant action. 6) Degree of provocated flight behavior or each drug in the following order; diazepam>nitrazepam>chlordiazepoxide.
社団法人日本薬理学会の論文