気道分泌物測定についての薬理学的考察

概要

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Drug effects on the secretion of respiratory tract (S.R.T.) are investigated in pharmacological studies, however, satisfactory methods to measure S.R.T. have yet to be devised. The authors measured the electrical resistance (E.R.) by means of an inserted electrode and the effects of certain drugs on S.R.T. were determined. The correlation of secretion patterns between S.R.T. and saliva was investigated in dogs. As a result, pilocarpine (0.05 and 0.5 mg/kg i.v.) decreased E.R. considerably while atropine (1.0 mg/kg i.v), adrenaline (5 μg/kg i.v.) and isoprenaline (5 μg/kg i.v.) increased E.R.. Noradrenaline (5 μg/kg i.v.) had no effect. The pattern of secretion appeared to be different between S.R.T. and saliva. Such being the case, the method utilized herein may be useful in detecting relatively small changes in the S.R.T..
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