イチジク葉の血圧下降成分

概要

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It was previously reported that the crystalline substance from petroleum ether extract of fig leaves (Ficus carica L.) showed hypotensive effect, but the active principles have been left to be clarified. The fig leaves were extracted with n-hexane and subsequently with methanol. The w-hexane extract afforded crystalline substance (II) which was further separated into two furocoumarins, psoralen (III) and bergapten (IV). The methanol extract was divided into ether (V), ethyl acetate (VI), w-butanol (VII) and water solubles (VIII) respectively. In hypotensive experiments of II〜VIII in rabbits, II and III showed prolonged actions on the blood pressure, but IV did a transient action. Also V containing III and IV, showed a weak prolonged action but the other fractions (VI〜VIII) did only weak transient actions. From these results it was concluded that psoralen (III) and bergapten (IV) are the main hypotensive principles of fig leaves.
日本生薬学会の論文
1975-12-20