生薬升麻の基源であるサラシナショウマ属及び近縁植物の成分

概要

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Cimicifugae Rhizoma have been used as an anti-inflammatory, analgesic and antipyretic remedy in the traditional Chinese medicines. Many 9,19-cyclolanostane glycosides have been isolated from Cimicifuga and related genera. Two biogenetically key compounds, acetylshengmanol xyloside and cimicifugoside H-1,were isolated and their chemical structures were elucidated by our group. The former compound seems to be the parent component of the other glycosides such as cimigenol xyloside, 25-O-acetylcimigenol xyloside, 25-O-methylcimigenol xyloside and cimigol xyloside from C. dahurica, C. iaponica and C. acerina. The latter glycoside, cimicifugoside H-1 was isolated together with cimicifugosides H-2-H-6 from commercial Cimicifugae Rhizoma. They are novel glycosides having a hydroxyl group at C-11,and cimicifugosides H-3,H-4 and H-6 were trinor-triterpenol glycosides. Cimicifugoside H-1 changed into H-2,H-3 and H-4 under acidic or alkaline conditions. In this review, the structure elucidation of the above glycosides and their chemical transformation into the other Cimicifuga glycosides are described.
社団法人日本薬学会の論文
1996-11-25