Studies on the Chinese Crude Drug "Shoma". IX. Three Novel Cyclolanostanol Xylosides, Cimicifugosides H-1,H-2 and H-5,from Cimicifuga Rhizome
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概要
- 論文の詳細を見る
Three new cyclolanostanol xylosides were isolated from a batch of commercial Cimicifuga Rhizome, cimicifugoside H-1 (1), C_<35>H_<52>O_9,mp 260-262℃, [α]_D -43.5°, cimicifugoside H-2 (2), C_<35>H_<54>O_<10>, mp 227-229℃, [α]_D -38.8°, and cimicifugoside H-5 (3), C_<35>H_<52>O_<10>, mp 262-264℃, [α]_D -22.9°, together with known glycosides, actein and 27-deoxyactein. Their structures were determined on the basis of chemical and spectrometric evidence including an X-ray crystallographic analysis. The structure of cimicifugoside H-1 (1) was established as (20R, 24R)-24,25-epoxy-11β-hydroxy-3-β-(β-D-xylopyranosyloxy)-9,19-cyclolanost-7-ene-16,23-dione. Cimicifugoside H-5 (3) is the 15-hydroxylated derivative of 1. Since 1 changed into cimicifugoside H-2 (2) on treatment with p-toluenesulfonic acid, 2 has a 24R, 25-diol structure derived from 1 by opening its epoxy ring.
- 社団法人日本薬学会の論文
- 1995-05-15
著者
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桜井 信子
東北大学薬学部
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永井 正博
星薬科大学
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永井 正博
Faculty of Pharmaceutical Sciences, University of Tokyo
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桜井 信子
星薬科大学生薬学教室
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永井 正博
星薬大
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小枝 守
Faculty of Pharmaceutical Sciences, Hoshi University
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青木 芳延
Faculty of Pharmaceutical Sciences, Hoshi University
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桜井 信子
Faculty of Pharmaceutical Sciences, Hoshi University
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永井 正博
星薬科大学生薬学教室
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永井 正博
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Addresses)hoshi College Of Pharmacy
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Aoki Y
Showa College Of Pharmaceutical Sciences
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Sakurai N
Faculty Of Pharmaceutical Sciences Hoshi University
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Koeda M
Faculty Of Pharmaceutical Sciences Hoshi University
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小枝 守
Faculty Of Phrmaceutical Sciences Hoshi University
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