Bitter Principles of Pertya glabrescens : Two Sesquiterpene Glucosides

概要

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Two bitter principles, glucosyl pertate (I), [α]_D -48.6°, and glucosyl 3α-hydroxypertate (II), [α]_D -10.9°, were isolated from the leaves of Pertya glabrescens SCH. BIP. (Compositae). On acid hdrolysis, I and II yielded new sesquiterpene acids, pertic acid (IV), C_<15>H_<18>O_4,mp152-153℃ (dec.), [α]_D -72.7°, and 3α-hydroxypertic acid (XI), C_<15>H<18>O_5,mp 250-252℃ (dec.), [α]_D +1.6°, as their genins, respectively. These genins were chemically correlated with pertilide (VI). The chemical structures of I and II were established as β-D-glucopyranosyl [1 (10) Z, 4E]-(7R, 8S)-germacra-1 (10), 4,11 (13)-trien-12,8-olide-14-oate (I) and β-D-glucopyranosyl [1 (10) Z, 4E]-(3R, 7R, 8S)-3-hydroxygermacra-1 (10), 4,11 (13)-trien-12,8-olide-14-oate (II).
公益社団法人日本薬学会の論文
1983-07-25