メニエ-ル病と血中ノルエピネフリン

概要

論文の詳細を見る
Blood pressure and plasma norepinephrine (P-NE) which was evaluated using GC-MS were measured in 9 healthy subjects and 17 patients with Meniere's disease. These values were compared in three different sequential conditions; i) supine position ii) erect position 5 min. after standing iii) erect position 10 min. after standing. P-NE value at supine position of patients with Meniere's disease was slightly lower than that of healthy subjects, though no significant difference was found between two groups.P-NE significantly increased at the erect position 5 min. after standing in both groups, however, this increment was larger in Meniere's disease than in control group.Mean blood pressure increased at this period in both groups, however, this increment was significantly lower in Meniere's disease than in control group.There was no such changes of P-NE and blood pressure at 10 min. after standing in both group.It may be suggested that the patients with Meniere's disease have a relative hyporesponsiveness of blood pressure to endogenously released catecholamine.