ノルアドレナリンの血液粘調度およびその規定因子に及ぼす影響--自律神経機能との関係 (前庭機能異常の研究-3-<特集>)

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It is well known that microcirculation is influenced by blood viscosity. We investigated the effects of noradrenaline (NA) infusion on the whole blood viscosity and viscosity's regulatory factors in order to elucidate the role of the sympatho-adrenal activity in microcirculation.The results are as follows.1. The whole-blood viscosity measured at five different shear rates proportionally increased as the plasma NA concentrations increased.2. The increments of the whole-blood viscosity after NA infusion (ΔCP) were greater at low shear rates than that at high shear rates.3. The mean ΔCP in sympathicotonic persons, who are so classified by autonomic nervous function tests, tended to be greater than that in nonsympathicotonic persons.4. The platelet aggregability, hematocrit, and contents of some plasma lipids and lipoproteins, which can influence the whole blood viscosity, also increased after NA infusion.Present data pointed out the possibility that the sympatho-adrenal hyperactivity may cause "the brain-inner ear circulatory insufficiency" due to impaired microcirculations being induced by the increased whole blood viscosity.
耳鼻咽喉科臨床学会の論文