めまい患者の自律神経機能

概要

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Plasma levels of norepinephrine (NE), which are useful index of sympathetic nervous function, were measured in vertiginous patients by gas chromatograph-mass spectrometer using selected ion monitoring method.There was no significant difference in the resting plasma NE levels between healthy subjects and patients groups such as Menieres disease, vertigo (central and peripheral origin) and sudden deafness.NE and blood pressure increased in all groups when the subjects were kept at the standing errect position. No significant differences were found in the increment of NE at the errect position, however, there was less elevation in blood pressure in patients groups, especially in Menieres disease patients.Using another patients group of subjecus such as Menieres disease and sudden deafness patients, pressor response for intravenously administered NE was studied. Menieres disease patients showed hyporesponsiveness of blood pressure to exogenously administered NE.These facts suggest that sympathetic effector organs in Menieres disease patients are functionally disturbed.
社団法人日本耳鼻咽喉科学会の論文