Fundamental and clinical studies on Cefoperazone in prophylaxis for otolaryngological surgery.

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The concentration of Cefoperazone (CPZ) in the soft tissues (mucous membrane of the pharynx, trachea and lymph node) and wound exsudates in patients undergoing major head and neck surgery was measured by high-pressure liquid chromatography.CPZ (4g) was infused over a 4-hour period. Simultaneous samples of serum and soft tissues were collected in 14 patients at 2 to 4 hours during infusion. CPZ (2g) was administered intravenously twice a day on the following day.Mean levels of CPZ in the mucous membrane of the pharynx and trachea and lymph node were 67.2μg/g, 36.0μg/g, 35.8μg/g, respectively. Excretion of CPZ into wound exsudates through the catheter was observed in 12 patients. Mean levels of CPZ in the wound exsudates were 80.7μg/ml (day 1), 35.5μg/ml (day 2), 42.5μg/ml (day 3).Clinical use of CPZ in 28 patients undergoing surgery showed no postoperative infection.Our experience showed that CPZ was particularly useful in prophylaxis for otolaryngological surgery.