Cefepime in Otorhinolaryngological Infections.

概要

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We investigated cefepime, a newly developed parenteral cephem antibiotic, in the treatment of otorhinolaryngological infections. Cefepime was injected intravenously in a total of 26 patients, 1.0g-2.0g for 2-8 days. The infections were otitis media 4, paranasal sinusitis 6, tonsillitis 13, other infections 3.The clinical response was excellent in 6, good in 14, fair in 5, no response in 1. The efficacy rate (excellent + good) was 80.0%. Especially in tonsillitis, the efficacy rate was very high (100%). The efficacy rate was higher for acute than for chronic infections.Of a total of 29 cultured bacteria, 24 were eliminated. The eradication rate was 92.3% excluding 3 strains whose bacteriological response was unknown. The eradication rate was over 90% for gram positive and gram negative bacteria.The tissue levels of cefepime were higher in the maxillary sinus mucosa than in the palatine tonsil.