フマル酸ベンシクレンの椎骨動脈血流および前庭眼反射におよぼす影響

概要

論文の詳細を見る
The effect of Bencyclane infusion on the velocity of blood flow in the vertebral artery was investigated in 6 normal subjects and 7 patients with unilateral peripheral vestibular disorder using the ultrasonic doppler method. Additionally, its effects on the vestibulo-ocular and opto-vestibular reflexes were examined in the same subjects using the damped pendular rotation test.Blood velocities of the vertebral arteries increased bilaterally by 30% of the pre-injection value after Bencyclane infusion in the normal subject group. Although a similar amount of increase was observed in the patient group in the vertebral artery of the intact side, a smaller amount of increase was found in the vertebral artery of the side of the lesion.The vestibulo-ocular (VOR) gain with eyes closed and the opto-vestibular (OVR) gain with the eyes open were measured. In the normal group, these were 0.69 and 0.96, respectively. There was no asymmetry of VOR or OVR gain in right or left rotation. After Bencyclane infusion, both gains were unchanged.In the patient group, on the other hand, VOR and OVR gains were 0.77 and 1.06, respectively, when the nystagmus beating away from the lesion side was measured. These values were 0.64 and 1.00, respectively, when the nystagmus beating to the lesion side was measured.Directional prepondelance of VOR and OVR gains in patients group tended to be improved after Bencyclane infusion.
耳鼻咽喉科臨床学会の論文