耳鼻咽喉科領域感染症におけるCefmetazoleの臨床的検討

概要

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We investigated the therapeutic effect of a cephamycin antibiotic, Cefmetazole (CMZ) on infections and its safety in the otolaryngological field with the following conclusions:1) CMZ was administered to 73 patients with infections in the otolaryngological field (28 with acute tonsillitis, 14 with peritonsillar abscess, 9 with acute epiglottitis, 3 with phlegmone in the floor of the mouth, 2 with acute suppurative submaxillar sialoadenitis, 2 with postoperative wound infection, one with acute exacerbation of chronic otitis media, one with acute sinusitis, and 6 with others). Of the 71 cases except for 2 dropouts, CMZ was collectively evaluated to be markedly effective in 31, moderately effective in 33 and slightly effective in 7. It was moderately to markedly effective in 90.1%.2) There was no significant difference in efficacy among diseases or between patients given 2g and those given 4g.3) CMZ was moderately to markedly effective in 21 of the 23 patients who had not responded to previous medications.4) Subjective or objective symptoms considered as side effects were not found. Clinical tests demonstrated increase in the number of eosinophils in one patient and rise in GOT, GPT, and Al-P levels in another.
耳鼻咽喉科臨床学会の論文