メニエ-ル病を中心とした末梢性耳性めまいに対する薬効検定の問題点(ATPによる薬量効果判定を中心に) (前庭機能異常の研究-2-<特集>)

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Vertigo is a subjective sensation, which is very difficult to evaluate. There are large variation in patients' thresholds. Therefore, the dose evaluation of medical treatment for Meniere's disease is a very difficult in clinical practice.In order to evaluate the antivertiginous dose response of ATP, both subjective and objective symptoms in 154 patients with Meniere's disease (69 cases) and other peripheral vestibular disorders (85 cases) were analyzed in a double-blind controlled study comparing doses of 300mg and 150mg daily for four weeks respectively. The clinical subjective and objective symptoms in these cases were evaluated at the first otoneurological examinations before prescribing treatment, the second after two weeks, and the last after four weeks, by the doctors and patients respectively. The method of giving medicine is the matched-pair-group-methods for this double-blind control trial. The statistical comparison between the effects of the two doses showed that the 300mg ATP dosage was significantly more preferred than the 150mg dosage when the subjective and objective gloval evaluation in these cases was analyzed. However, no significant preference between the two dosages was revealed in vertigo and/or dizziness. The statistical comparison between the two dosages, on the other hand, showed its more significant difference in spontaneous nystagmus, positional nystagmus and caloric nystagmus tests.Therefore, it should be emphasized that the statistical analysis between the two dosages of such antivertiginous drug in the double-blind controlled study of the matchedpair-groups should be applied for determination of the maximum dose response in patients with vertigo and/or dizziness.
耳鼻咽喉科臨床学会の論文

メニエ-ル病を中心とした末梢性耳性めまいに対する薬効検定の問題点(ATPによる薬量効果判定を中心に) (前庭機能異常の研究-2-<特集>)

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