メニエ-ル病のフロセミドテスト--中心および偏心振子様回転検査による (内藤儁教授退官記念論文集)

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We applied the furosemide test using centric & eccentric pendular rotation stimuli to the patients with Ménière's disease for the purpose of diagnosis of endolymphatic hydrops. In patients with probable Ménière's disease, after the administration of furosemide in doses of 20mg intravenously, the difference of the directional preponderance index of the centric & eccentric pendular rotation test improved to within normal ranges, as a result of prompt diuretic activity.In this report, we evaluated 60 patients with Ménière's disease and 25 patients with vertigo due to peripheral labyrinthine origin except Ménière's disease or central origin for the control.Twenty seven of 60 patients with Ménière's disease (45%) were positive in the furosemide test. In these patients, positive test results were seen in 25 of 39 patients (64%) in the attack stage, but in the period of remission were seen in 2 of 21 patients (10%).None of 25 patients with vertigo except Ménière's disease showed a positive furosemide test.Hearing improvements after furosemide administration were seen in about a half of affected ears of patients with Ménière's disease in the ranges of 1 to 10dB in the average of hearing threshold levels from 250, 500 and 1000Hz.Changes of subjective symptoms, particularly dizziness and tinnitus, after furosemide injection, were hardly seen in the patients with Ménière's disease or non-Ménière's disease.
耳鼻咽喉科臨床学会の論文