Azelastine Hydrochloride Treatment of Allergic Rhinitis. Multi-Hospital Clinical Study in Nara Prefecture.:-Multi-Hospital Clinical Study in Nara Prefecture-

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The effects of azelastine were investigated in 23 patients with perennial and 57 with seasonal allergic rhinitis seen in our institutions between October 1986 and April 1988. The antigen in seasonal allergic rhinitis was identified as Japanese cedar pollen in 45 patients and cock's footgrass in 12.1. In the rating general improvement of the response was classified as moderate or better in 47.8% of those with perennial rhinitis and as slight or better in 82.6%. The corresponding values for seasonal rhinitis were 57.9% and 84.2%. The combined ratings were 55.0% and 83.8%, respectively.2. Treatment reduced the following symptoms: sneezing, nasal secretions, nasal obstruction, disturbances in daily living, and volume of secretion.3. Japanese cedar pollinosis was treated in 25 patients in 1987 and in 20 in 1988. The general improvement ratings were 40.0% and 68.0% in 1987 and 75.0% and 95.0% in 1988. Considering that in 1988 the Japanese cedar pollen count was four times that in 1987 the difference in the general improvement rating between the two years may be due more to the duration of treatment than to the pollen count.4. Drowsiness as an adverse reaction was noted in 4 of the 80 patients, and treatment was discontinued in one.5. In general utility the drug's usefulness was rated as moderate or better in 47.8% of the perennial rhinitis patients and as slight or better in 78.3%. The corresponding values for the seasonal rhinitis patients were 57.9% and 84.2%, respectively. The general utility ratings for both types combined were 55.0% and 82.5%.

Azelastine Hydrochloride Treatment of Allergic Rhinitis. Multi-Hospital Clinical Study in Nara Prefecture.:-Multi-Hospital Clinical Study in Nara Prefecture-

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