ラットの一側椎骨動脈閉塞時の両側蝸牛血流動態の観察

概要

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It is well known that some kinds of vertigo and some hearing problems are caused by impairment of the vertebro-basilar circulation. The influence of unilateral vertebral artery (VA) occlution on bilateral inner ear blood flow was studied in rats by the laser Doppler method. After tracheotomy, both cochleas were exposed through a ventral approach for the measurement of cochlear blood flow (CBF). One VA was occluded by photochemically induced thrombosis. The right femoral artery was cannulated for continuous measurement of systemic blood pressure (BP). BP and CBF showed little change after unilateral VA occlu-sion alone. However, subsequent hypotension induced by venesection not only reduced CBF, but also caused bilateral imbalance between the CBF reduction rates. CBF changed independently of BP, indicating the existence of a local CBF regulation system.