耳鼻咽喉科領域の急性感染症に対するCefmenoximeの使用経験

概要

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Cefmenoxime was intravenously given 2 to 8 days to 14 patients with acute infectious diseases in the field of otolaryngology: 8 with peritonsillar abscess, 2 with tonsillitis, 1 with paranasal sinusitis, 1 with acute exacerbation of otitis media chronica and 2 with postoperative maxillary cyst (acute exacerbation). Daily doses of cefinenoxime were 1 to 2 grams. The response was excellent in 6 patients, good in 7 and fair in 1. The rate of satisfactory (excellent and good) responses was 92.9%.Peptococcus, Bacteroides melaninogenicus, B. fragilis, Peptostreptococcus, Klebsiella pneumoniae, Enterobacter cloacae, Streptococcus pyogenes and S. aureus were isolated from the patients as causative pathogens. Cefmenoxime showed more potent antibacterial activities against B. melaninogenicus, B. fragilis, Klebsiella and S. pyogenes than cefazolin or cefotiam. No side effects or abnormal laboratory findings were observed.
耳鼻咽喉科臨床学会の論文