Clinical examination of nicardipine HCl(perdipine) in vertiginous patients.

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Perdipine tablets containing 20mg of nicardipine HCl were administered to 54 patients complaining chiefly of dizziness, three times a day for 4 weeks, and the clinical usefulness of the drug was studied.The rate of efficacy against dizziness (patients belonging to this category include those in whom the drug had "good" and "excellent" effects) was 73.9%. The rate was 79.4% in patients in whom the drug was administered alone (group A) and 58.3% in patients in whom the drug was used in combination with other drugs (group B). The general rate of improvement for accompanying systems ranging from slight to marked was 63.4%. The rate was 60.0% in group A and 72.7% in group B. The rate was relatively high for nausea, vomiting, headache, tinnitus, and stiff shoulders. After equilibrium tests, the general rate of improvement was 71.4%:the rate was 78.6% in group A and 57.2% in group B. The rate was high for spontaneous nystagmus, positional nystagmus, and head shaking after nystagmus. The rate of usefulness (ranging from possibly useful to clearly useful) was about 75% in both groups. Ten of 12 patients who showed positive reactions to the Schellong test before treatment showed negative reactions after administration of the drug. In patients with hypertension, the drug showed marked hypotensive action, but in patients with normal blood pressure, the action was mild. The incidence of side effects was 13.0%.
耳鼻咽喉科臨床学会の論文