TDI鼻感作モルモットに対するステロイド点鼻

概要

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To determine whether topical corticosteroid inhalation inhibits symptoms of nasal allergy, we studied toluene 2, 4-diisocyanate (TDI)-sensitized guinea pigs as an experimental model of nasal allergy. TDI-sensitized guinea pigs were challenged with TDI after treatment with a nasal spray of beclomethasone dipropionate. In animals not treated with beclomethasone, TDI cuased nasal allergy like signs: sneezing, nasal discharge, nasal obstraction and decreased histamine in the nasal mucosa. TDI-induced signs were markedly reduced in the groups challenged with TDI 15 and 30 minutes and 1, 2 and 3 hours after beclomethasone treatment, and the decrease of histamine content was prevented in the groups challenged with TDI 15, 30 minutes and 2 hours after beclomethasone treatment. These results indicate that the topical application of beclomethasone dipropionate is effective in the suppression of TDI-induced nasal allergy-like signs and suggest that beclomethasone inhibits histamine release from mast cells in the nasal mucosa induced by TDI challenge.
耳鼻咽喉科臨床学会の論文