鼻アレルギ-減感作治療における喘息の影響

概要

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This study was undertaken to evaluate the effects of hyposensitization in 435 patients on the nasal allergy with or without extrinsic asthma. There were 360 patients with nasal allergy uncomplicated with asthma. Specific and nonspecific IgE, numbers of eosinophils in the blood and nasal secretion, and subjective nasal symptoms were employed as parameters.The incidence of abnormally high serum IgE, specific IgE and blood eosinophils was found to be higher in the patients with nasal allergy with asthma than those uncomplicated with it. The difference in the incidence was statistically significant. There was no significant difference in the incidence of the patients with abnormally increased eosinophils in both blood and nasal secretion between the patients with or without asthma.During the course of hyposensitization over one year, it was found that it was only the number of eosinophils in the nasal secretion which was significantly decreased. In the patients with nasal allergy uncomplicated with asthma, the appearance of the blocking antibody was significantly increased after a one-year course of immunotherapy. Other parameters were not changed in the patients with or without asthma.It was concluded that the parameters examined were almost identical and that nasal allergy with or without asthma might be improved by hyposensitization over one year.
耳鼻咽喉科臨床学会の論文