慢性副鼻腔炎鼻汁の研究

概要

論文の詳細を見る
Physico-chemical properties of human nasal secretions from health and disease are not well defined. It is likely that nasal secretions reflect pathological circumstances in the nose and paranasal sinuses. Therefore, analysis of physico-chemical properties of the nasal secretions may lead to the better understanding of the pathogenesis and facilitate evaluation of the severity and therapeutic effects of the diseases in the nose and paranasal sinuses.Measurement was made of the pH, relative viscosity, dry matter, protein and polysaccharide in the nasal secretions from 16 patients with chronic sinusitis who were so diagnosed by rhinoscopy and radiology. The pH and relative viscosity averaged 7.50±0.66 and 17.4793±23.3786, respectively. Dry matter, protein and polysaccharide in the chronic sinusitic nasal secretions averaged 54.2mg/g±17.2, 30.5mg/g±19.1 and 3.53mg/g±1.92, respectively. They were considerably higher than those obtained from control subjects. Significant correlations were noted among dry matter, protein and polysaccharide.A nasally administered drug appears to be trapped in the mucus layer and interacts with nasal secretions. When passing through the nasal cavity to the pharynx by way of mucociliary clearance, the drug may be absorbed by or injure the nasal mucosa. The pH of pooled nasal secretions diluted 8-fold by distilled water of pH 3.0-7.0 turned out to be 7.0-8.0. The pH of pooled nasal secretions diluted 8-fold by various drug solutions in distilled water or saline of pH 5.0-7.0 was 7.0-8.0. DOX and lysozyme in a concentration of 2% in distilled water aggregated pooled nasal secretions in vitro. This indicates that the nasal secretions from chronic sinusitis patients possess a strong buffering capacity and the solvent used for dissolving the drug has an important role in the topical treatment of nasal illnesses.
耳鼻咽喉科臨床学会の論文

慢性副鼻腔炎鼻汁の研究

スポンサーリンク

概要

著者

関連論文

スポンサーリンク