ヒト口蓋扁桃における分泌型IgA (三吉康郎教授開講20周年記念論文集)

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A considerable number of investigations on the local immune defense mechanism have shown that the secretory component (SC) may not be synthesized in the palatine tonsil in humans. To investigate the local immune system, especially the secretory IgA system in human palatine tonsils, the present study was designed to identify the distribution of IgG-, IgA-, IgM- and IgE-containing cells and 10S IgA-containing cells which could be distinguished by the intracytoplasmic SC-affinity test and the existence of secretory component. By immunoelectrophoretic and gel diffusion studies, quantitative determination of secretory IgA in the tonsil was made.Immunoglobulin-containing cells were found in 4 compartments of the tonsils, most of which were located in the extrafollicular areas; IgM containing cells were frequently present in the germinal center. The tonsillar immunocytes population showed an overall IgG:IgA:IgM:IgE class ratio of 58.1:34.0:5.8:2.1. The tonsil was not stained for SC. However, the glandular lumen and intercellular spaces of the Weber's glands were faintly stained for SC. 10S IgA-containing cells were detected in the crypt area of the tonsil and Weber's glands. Furthermore, 11S IgA was detected by immunoelectrophoresis and immunodiffusion in the tonsil extracts.Although the major local immune defense of the palatine tonsil may depend on the salivary fluid, we proposed a hypothetical model for the transport of 10S IgA and 10S IgA-containing cells across the crypt epithelium and for conjugation with the free secretory component (FSC) derived from saliva in the crypt lumen on the palatine tonsils.
耳鼻咽喉科臨床学会の論文

ヒト口蓋扁桃における分泌型IgA (三吉康郎教授開講20周年記念論文集)

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