慢性副鼻腔炎鼻汁の研究-4-S-carboxymethylcysteineの鼻粘膜粘液繊毛輸送機能に及ぼす影響

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This study evaluates the effect of S-carboxymethylcysteine (SCMC), a newly developed expectorant, on nasal mucociliary clearance and rheological properties of nasal secretion in patients with chronic sinusitis. SCMC was administered in a dose of 1500mg/day orally for four weeks. Nasal mucociliary clearance and nasal mucus were examined before, and two and four weeks after the start of administration.Nasal mucociliary clearance (nasal ST) was measured by the saccharin granule method in 15 patients. At week 0, nasal ST was within the normal range in 8 patients (group A) and was above normal in 7 patients (group B). At two weeks, the nasal ST of group A and of group B was not significantly different from that at week 0. At four weeks, the nasal ST was significantly better than that at week 0 in group B (p<0.005), but was not in group A.Fifteen nasal mucous samples were collected from the nasal cavity by aspiration. The rheological property of the mucus was determined by the mucociliary transport rate on the mucus depleted frog palate. The mucociliary transport rate (MTR) on the frog palate at week 0, week two and week four was 19.61±10.51mm/min, 19.03±6.50mm/min and 17.04±6.15mm/min, respectively. The MTR on the frog palate did not change significantly during the period of administration. These results indicate that the effect of SCMC on nasal mucociliary clearance is not due to modification of the rheological properties of nasal secretion, but may be due to other factors.SCMC was considered to be a useful drug in the conservative treatment of chronic sinusitis.
耳鼻咽喉科臨床学会の論文

慢性副鼻腔炎鼻汁の研究-4-S-carboxymethylcysteineの鼻粘膜粘液繊毛輸送機能に及ぼす影響

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