セアプロ-ゼSの慢性副鼻腔炎に対する効果

概要

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The effect of proteolytic enzyme, Seaprose-S, on chronic sinusitis was examined. Subjects of this study included a total of 64 patients comprising 28 men and 36 women aged from 18-80 years old. The patients received Seaprose-S 15mg p. o. three times a day. No antibiotics or other proteolytic enzymes were given to the subjects. The effectiveness of Seaprose-S was evaluated by the parameters based on subjective symptoms, rhinoscopic observation and X-ray findings. In regard to subjective symptoms, the percentage of patients who felt good effects from the drug was 60.7% for nasal obstruction, 57.4% for nasal discharge and 54.1% improvement of difficulty in blowing the nose.In regard to rhinoscopic observations, the effectiveness of the drug on the amount of nasal secretion and properties of nasal secretion was observed in 55.7% of the patients.In X-ray findings, the effectiveness of the drug was observed in 37.5% of the maxillary sinuses and 28.3% of the ethmoid sinuses. The general effectiveness estimated from these results were excellent in 1 case (1.6%), good in 21 (32.8%), fair in 27 (42.2%) and poor in 15 (23.4%). A side effect of the drug was observed in one patient who complained of stomach-ache.Seaprose-S was considered to be a useful drug for conservative treatment of chronic sinusitis.