鼻粘膜からの抗生物質の吸収について

概要

論文の詳細を見る
The antibiotics, Sulfobenzyl-Penicillin (SB-PC) and Aminodeoxykanamycin (AKM), administered nasally by nebulizer were taken up by nasal mucosa and transported to the circulation. A microbiological agar diffusion method was used for the antibiotics assays in the serum. In 6 of 12 patients with chronic sinusitis administered nasally SB-PC in a dose of 500mg, the SB-PC activity was detected, while in 1 of 11 control subjects the activity in the serum was detected, . The difference for the ratio of detection of SB-PC activity in the serum was statistically significant between the patients with chronic sinusitis and control (P<0.025). At one hour after nasal administration of AKM in a dose of 100mg, the mean concentration in the serum was 0.75mcg/ml±0.21 in 15 chronic sinusitis patients, and 0.51mcg/ml±0.11 in 19 control subjects. The difference of mean AKM concentration between patients and control was highly significant (P>0.005). These facts indicate that chronic inflammatory change of the nasal mucosa may enhance the uptake of antibiotics by nasal mucosa.
耳鼻咽喉科臨床学会の論文