Sjogren症候群について

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Thirty-five cases of Sjögren's syndrome were presented. These cases were analyzed in terms of age, presenting symptoms, laboratory findings and immunoserological examinations, sialographic findings of the parotid gland, histopathological findings of the minor salivary gland in the lower lip and ophthalmological examination. Taste, smell and nasal mucociliary function were examined in certain subjects.All the patients were female. The average age was 47.9 years at the time of diagnosis. Sixteen patients had sicca syndrome alone and 19 were complicated by connective tissue disorders. There was no statistically significant difference in the results of the above mentioned analyses but ESR between the two groups.Keratoconjunctivitis sicca was noted in 75% and enlargement of the salivary glands was present in 43% of the patients. Hypergammaglobulinaemia was present in 90% and a marked elevation of IgG was found with a slight increase in IgA and IgM levels. Rheumatoid factor was positive in 80% of the patients.Parotid sialograms revealed severer changes than punctate sialoectasis in all the patients. The most prevalent finding in sialograms was globular sialoectasis, which was found in 45.7% of the patients. In labial biopsy, more than moderate infiltration of lymphoid cells was observed in the minor salivary gland. Focal involvement of lymphoid cells was predominant in 56.7% of the patients. Sialographic and histopathological studies correlated well. However, there was a tendency toward higher scoring in the histopathological findings than the sialographic. Both sialographic and histopathological examinations were essential for the diagnosis and evaluation of the severity of the disease.A general discussion on the methods of treatment was also given, including steroid, radiation and immunosuppresive therapies.
社団法人日本耳鼻咽喉科学会の論文

Sjogren症候群について

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