咽喉頭異常感症に対する抗うつ剤dosulepin hydrochlorideの効果

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Depressive state is frequent in patients with abnormal sensation in the throat (AST). It is still not certain, however, that depression can cause AST. In some cases, prolonged AST may cause a depressive state.We assumed that anti-depressants would be effective for patients with AST caused by depression or those with AST combined with a depressive or an apprehensive state, and administered an anti-depressant, Prothiaden 25® (1-2 Cap/day), for two weeks to 64 patients with AST. Five patients were excluded, in one whom side effects were so severe that the medication had to be suspended and 4 who dropped out before the evaluation. The therapeutic effects of the medication were evaluated in the remaining 59 patients (27 males and 32 females) at the end of the first week and of the second week of administration and one week after the termination of treatment. It was considered to be effective when the AST improved subjectively by 50% or more. Among the 59 patients, the medication was effective in 42% in one week, in 56% in two weeks and in 54% in three weeks (one week after the termination of treatment). These efficacy rates are rather low in comparison with those we obtained previously with a minor tranquilizer and/or an anti-inflammatory agent. It was obvious that this anti-depressant was more effective in 19 patients with depressive state than in 40 non-depressed patients. The efficacy rates were 47% in one week, 63% in two weeks and 68% in three weeks in the former, and 40%, 53% and 48%, respectively, in the latter.We conclude that anti-depressants are of value in the therapy of patients with AST who are suspected of being depressed.
耳鼻咽喉科臨床学会の論文

咽喉頭異常感症に対する抗うつ剤dosulepin hydrochlorideの効果

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