Clinical evaluation of Piroxicam for abnormal sensation in the throat.

概要

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A double blind test was carried out to evaluate the efficacy of Piroxicam (a non-steroidal anti-inflammatory agent) on abnormal sensation in the throat. Piroxicam combined with Diazepam was administered to 63 patients with abnormal sensation (such as feeling of a lump) in the throat and placebo combined with Diazepam to 63 patients for 2 weeks. The therapeutic effects of the medication were evaluated at the end of the first and second week of administration and one week after the termination of treatment. It was considered to be effective when the abnormal sensation improved subjectively by 50% or more. In 3 of the 63 patients to whom Piroxicam and Diazepam were administered, side effects were so severe that the medication had to be suspended. Among the remaining 60 patients, the medication was effectivte in 70% in one week, in 76% in two weeks and in 68% in three weeks. Among the 63 patients treated by placebo combined with Diazepam, the medication was effective in 65% in one week, in 62% in two weeks and in 55% in three weeks. The present study indicates that Piroxicam is effective in the therapy of abnormal sensation in the throat.
耳鼻咽喉科臨床学会の論文