Effect of tiaprofenic acid on abnormal sensation in the throat.

概要

論文の詳細を見る
If the main cause of abnormal sensation in the throat is inflammation of the region, a majority of the patients with this symptom should respond to anti-inflammatory drug therapy.To test this hypothesis the authors assessed the efficacy of anti-inflammatory agents in such patients. The present study showed that tiaprofenic acid administered orally for two weeks was effective in 43% of 99 patients with abnormal sensation in the throat after one week, in 56% after 2 weeks and in 61% after 3 weeks (one week after the termination of treatment). Treatment was considered to be effective when the abnormal sensation improved subjectively by 50% or more. The effect appeared more quickly than when lysozyme chloride was used to treat this condition in our previous study. Both tiaprofenic acid and lysozyme chloride are anti-inflammatory drugs, but the former also has a peripheral analgesic effect. We assumed that the peripheral analgesic effect might block the nerve conduction of the abnormal sensation in the throat. The rapid effect was believed to be due to the analgesic action of tiaprofenic acid.
耳鼻咽喉科臨床学会の論文