Effect of Metharmon-F in middle-aged female patients with abnormal sensation in the throat.

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The authors administered Metharmon®-F, one tablet of which contains 1.0mg of pregnenolone, 0.1mg of testosterone, 1.0mg of androstenedione, 5μg of estrone, 0.5mg of androstenediol and 7.5mg of desiccated thyroid, orally for two weeks in a dosage of 3 tablets/day to 53 female patients aged 35 to 67 years with abnormal sensation in the throat. In 4 patients, side effects (sleeplessness, perioral paresthesia, nausea and diarrhea) were so severe that the medication had to be suspended. The therapeutic effects of the medication were evaluated in 49 patients at the end of the first and second week of administration and one week after the termination of treatment. It was considered to be effective when the abnormal sensation improved subjectively by 50% or more. The medication was effective in 39% of the patients within one week, in 49% in two weeks and in 51% in three weeks (one week after the termination of treatment). Recurrence of the symptoms shortly after the termination of treatment was rare and some patients showed further improvement.
耳鼻咽喉科臨床学会の論文