当教室〔三重大学耳鼻咽喉科学教室〕における鼻アレルギ-減感作療法の遠隔成績 (三吉康郎教授開講20周年記念論文集)

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One hundred and twenty-two patients (treated group) with allergic perennial rhinitis completed a one to six-year course of hyposensitization treatment with house dust extracts. Seventeen allergic patients (interrupted group) who received immunotherapy for 11 to 38 months with a mean of 25 months had interruption of treatment for 6 to 43 months with a mean of 17 months. Clinical significance of immunotherapy has been evaluated by comparing the duration of treatment with the following parameters: nasal symptoms and signs, nasal provocation test and skin test against house dust, numbers of eosinophils in nasal secretion and blood, concentration of specific and nonspecific serum IgE, and blocking antibody activity.In patients with severe or moderate symptoms, improvement in nasal symptoms was found in 74% of 84 patients of the treated group and 90% of 10 of the interrupted group. There was a correlation between the duration of treatment and the ratio of improvement in nasal symptoms in the treated group. Improvement in nasal symptoms in the interrupted group was present for at least one year. There was no correlation between the duration of treatment and the clinical findings except blood eosinophilia. Although the blocking antibody activity had been found in 13% of the patients prior to immunotherapy, it was found in 58% of the treated group and 35% of the interrupted group after therapy. There was a statistically significant difference between the treated and nontreated groups. There was a correlation between the appearance of blocking antibody and the duration of treatment but the appearance did not correlate with the improvement of nasal symptoms.These findings suggest that continuation of immunotherapy with house dust extracts for one and a half to two years in patients with severe or moderate nasal allergic symptoms is recommendable and after completion of this course the clinical symptoms may be maintained of the improved level for more than one year.
耳鼻咽喉科臨床学会の論文

当教室〔三重大学耳鼻咽喉科学教室〕における鼻アレルギ-減感作療法の遠隔成績 (三吉康郎教授開講20周年記念論文集)

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