小児の顕性と潜在性鼻アレルギー患者の鼻粘膜過敏性と鼻汁中ヒスタミン量

概要

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Nasal mucosal hypersensitivity to histamine and acetylcholine and kinetics of histamine content of nasal secretion in pediatric patients with manifested and non-manifested nasal allergy were studied.Nasal secretion were collected after 5 minutes of provocation with house dust or acetylcholine. Histamine was measured by fluorometric assay. The threshold for nasal hypersensitivity to histamine and acetylcholine in non-manifested nasal allergy of asthmatic patients was significantly higher than that in the manifested nasal allergy, but lower than that in the control group. The total or unit histamine content before provocation in the nasal allergy group was significantly higher than that in the asthma group and there was significant increase of total histamine content in each group after provocation with house dust or acetylcholine. But, histamine content after provocation by house dust or acetylcholine was not significantly different between the nasal allergy and the asthma groups.It was suggested that nasal mucosal hypersensitivity was more important factor than histamine content in nasal secretion for the manifestation of nasal allergy.
社団法人日本耳鼻咽喉科学会の論文