粘液繊毛輸送機能に及ぼす重力の影響

概要

論文の詳細を見る
Mucociliary clearance by the nasal mucus from the patients with chronic sinusitis (CS mucus) and the patients with nasal allergy (A mucus) was studied with and without load of gravity. The mucus from the different source had quite different macroscopic appearance. The CS mucus was highly viscoelastic and mucoid or mucopurulent. The A mucus was less viscoelastic or watery. The mucociliary transport rate of the mucus on mucus depleted frog palate was measured at horizontal position. The mucociliary transport rate was 6.71±1.49mm/min in CS mucus and 5.49±3.62mm/min in A mucus. This difference was not statistically significant.In the diseases of respiratory tract, where the mucus is hypersecreted, gravity may have the important influence on mucociliary clearance. To investigate the role of gravity on mucociliary clearance in hypersecreted state in vitro, 100μl mucus was pooled in a container and rectangular strip (about 3cm. in length and 1cm. in width) of palatal mucosa obtained by excision from mucus depleted frog palate was stood upright in the mucus. The weight of mucus carried by frog cilia against force of gravity for 5 minutes was measured. The weight percentage of the mucus, which was carried, to 100μl mucus was designated as Transported Amount of Mucus at 90 degrees (TAM-90). TAM-90 was 60.36±27.44% in CS mucus and 15.38±9.40% in A mucus. This difference was statistically significant (p<0.005). The results indicated that low viscoelastic mucus, such as A mucus, is not carried effectively by cilia in the load of gravity when the mucus is hypersecreted.

粘液繊毛輸送機能に及ぼす重力の影響

スポンサーリンク

概要

著者

関連論文

スポンサーリンク