Nasal hyperreactivity in guinea pigs treated with nebulized MS-antigen.

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Nasal hyperreactivity was induced in guinea pigs by the intranasal installation of toluene diisocyanate (TDI). The signs and symptoms of nasal hyperreactivity were observed, histamine assays of the nasal mucosa, lungs and blood were performed, and the nasal mucosa was examined histologically.Treatment with nebulized MS-A did not change the symptoms and signs, but it did increase the survival rate. The symptoms of 4 animals were improved, but in 2 they became worse. The histamine content of the tissues of animals treated with 20mg/ml of nebulized MS-A were lower than that of those treated with 4mg/ml of MS-A or saline. The histological study showed more basophilic cells in the epithelium of the animals treated with nebulized MS-A than in the controls. This finding was not related to the effect of this treatment.These results suggest that nebulized MS-A may cause migration of basophilic cells to the epithelial layer and inhibit histamine synthesis within basophilic cells or inactivate free histamine secreted by the cells of the nasal mucosa.
耳鼻咽喉科臨床学会の論文