:II. Clinical Study to Compare it with Other Antihistamines in Respect to an Adverse Side Effect (Drowsiness)

概要

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Mequitazine was administered to 72 patients with nasal hypersensitiveness, who complained of "drowsiness" with the use of ordinary antihistamines. Its clinical efficacy and incidence of "drowsiness" were evaluated.1) The clinical efficacy of mequitazine was rated as "Effective" in 66.7% and as "Slightly Effective" or better in 87.5% of the cases.2) When mequitazine was compared with reference standards "drowsiness" was reported to be slighter in 90%.3) With respect to "Usefulness", mequitazine was equal to ordinary antihistamines but inferior to betamethasone combinations.4) Subjective adverse side effects of "drowsiness" and "fatigue" were complained of but judged to be very slight. The subjective symptom of "thirst", which was attributable to the anticholinergic action of mequitazine, was reported in 5.6% of the cases.The general conclusion drawn from these results is that the incidence of the adverse side effect of "drowsiness" is so low that mequitazine is recognized as a useful drug when compared with ordinary antihistamines.
耳鼻咽喉科臨床学会の論文