鼻茸に対する局所ステロイド療法

概要

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The clinical effectiveness of topical steroid therapy and histological findings and changes in mediators were investigated in patients with nasal polyps.The subjects were 37 patients with similar polyps in both nasal cavities. Unilateral excision of a nasal polyp was performed in 31 patients, and the opposite nasal cavity was sprayed with a powdered mixture of beclomethasone dipropionate and hydroxy propylcellulose (BDP) for one week. After examination of the nasal cavity and assesment of the symptoms, the polyps were excised. Six patients who were not treated with BDP served as controls. Comparisons were made of the polyps and of the symptoms before and after BDP treatment in the treated group, and between it and the control group. The degree of improvement, clinical history, histological appearance and chemical mediators (leukotrienes, prostagladins, histamine, etc.) were also assessed and compared.The topical application of a steroid tended to reduce the size of the polyp and to improve the symptoms. There was a clearly superior overall degree of clinical improvement in comparison with the non-treated group.The histological findings and chemical mediators were not significantly different between the steroid-treated and non-treated sides.
耳鼻咽喉科臨床学会の論文